millrefa.blogg.se - Capto q impres

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These features, in combination with the well-established SP and Q ligands, make Capto SP ImpRes and Capto Q ImpRes an excellent choice for reliable intermediate purification and polishing in a commercial setting. Capto ImpRes media are based on a high-flow agarose base matrix with good pressure/flow properties (Fig 3) and a small bead size (approx. The strong ion exchange ligand groups of Capto SP ImpRes (left) and Capto Q ImpRes (right) are well established in large-scale purifications. The ligand of Capto SP ImpRes is a sulfonate group while the ligand of Capto Q ImpRes is a quaternary amine group (Fig 2). Chromatography media characteristics Ionic groups and base matrix Capto SP ImpRes and Capto Q ImpRes are strong cation and strong anion exchangers, respectively. Capto SP ImpRes and Capto Q ImpRes extend the well-established Capto platform to include high-resolution media for late intermediate purification and polishing. Security of supply and comprehensive regulatory support Fig 1.Higher manufacturing productivity enables improved process economy.High-throughput purifications easy to optimize and scale up.Flexible process design due to large operational window of flow rates and bed heights.High-resolution intermediate purification and polishing based on the well-established Capto platform with traditional ligands.

Key benefits of Capto SP ImpRes and Capto Q ImpRes include: Based on the well-established Capto base matrix and with traditional ionic group ligands, they provide many opportunities for improved productivity and straightforward process development. Capto SP ImpRes and Capto Q ImpRes are BioProcess chromatography media developed for large-scale purification of biopharmaceutical proteins. The ability to run at higher flow rates and higher bed heights also increases flexibility in process design. By combining the high-flow characteristics of Capto media with a small particle size, Capto SP ImpRes and Capto Q ImpRes deliver excellent pressure-flow properties with impressive resolution. Both chromatography media (resins) are part of an expanded high-resolution platform based on the high-flow agarose Capto product line. GE Healthcare Life Sciences Data file 28-9837-63 AB Ion exchange chromatography Capto SP ImpRes Capto Q ImpRes Capto SP ImpRes and Capto Q ImpRes are strong cation and strong anion exchangers for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules.